"Another disaster! Derailing at 3am (0100 GMT) in Tanganyika (province) near Mayibaridi. Provisional toll: 50 dead and several injured," he wrote.
Railways in the DRC have a poor record for safety, hampered by poor tracks and decrepit locomotives, many of them dating from the 1960s.
In March, at least 24 people were killed and 31 were injured Sunday when a freight train carrying illegal passengers crashed in the central region of Kasai.
In November last year, 10 stowaways were killed and 24 injured near the eastern town of Samba when the brakes failed on a freight train.
In November 2017, 35 people were killed when a freight train carrying 13 oil tankers plunged into a ravine in southern Lualaba province.
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